University Medical Center in Groningen (UMCG) – NL

UMCGGeneral description

The University Medical Center in Groningen (UMCG) is the largest academic teaching hospital in the Netherlands. It hosts 10000 employees and teaches 4000 students.

Three closely collaborating departments of the UMCG will be involved in RESOLVE: (i) the laboratory of Liver, Digestive and Metabolic Diseases (headed by Prof. Dr. A.K. GROEN), (ii) the department of Molecular Genetics (headed by Prof. Dr M.H. HOFKER) and (iii) the Systems Biology Center of Energy Metabolism and Ageing (chair: Prof. Dr A.K. GROEN).

Websites

www.umcg.nl
www.labpedriaticsrug.nl
www.rug.nl/fwn/onderzoek/programmas/biologie/SystemsBiology/research
www.rug.nl/moleculargenetics

Expertise

The members of the UMCG groups have a broad experience in studying lipid and carbohydrate metabolism at both the genetic and metabolic level primarily in mouse models but more recently as well in humans. To quantify control of metabolic fluxes the groups use state of the art stable isotope based fluxomics approaches using computational modelling to analyze the results. The groups have considerable expertise in systems genetics techniques and for this purpose lead of mouse clinic to be able to generate transgenic mice. One of the PIs (BAKKER) has a broad experience in computational modelling of metabolic networks to analyze complex phenotypes and identify drug targets.

Facilities

Quantitative metabolomics, fluxomics, mass isotopomer dilution analysis, enzymology, cell culturing, mouse transgenic facility, proteomics/metabolomics facility, computational systems biology tools. Access to the LifeLines cohort for studies on healthy ageing. Direct access to patients with MetS and families with mutations in triglyceride (TG) and HDL genes. Facilities to realize clinical intervention trials.

Other EU Projects

The UMCG has been involved in several EU projects; the PIs directly involved in RESOLVE have been involved in HEPADIP (Hepatic and adipose tissue and functions in the metabolic syndrome – FP6-LIFESCIHEALTH – Project ref: 018734); HDLOMICS (Functional Genomics of Inborn and Therapeutic Interventionw of High Density Lipoprotein – FP6-LIFESCIHEALTH – Project ref: 037631); NUCSYS (Systems biology of nuclear receptors: A nutrigenomics approach to aging-related disesases – FP6 MOBILITY – Project ref: 19496); UniCellSys (Eukaryotic unicellular organism biology systems biology of the control of cell growth and proliferation – FP7-HEALTH – Project ref: 201142).