Universitaet Zuerich (UZH) – CH

zurichGeneral description:

UZH is one of the leading research universities in Europe (world rank 51, European rank 12). Together with the neighboring ETH Zurich (world rank 26, European rank 4), UZH has established Life Science Zurich as a high-performance network in the area of biomedicine. Websites: http://www.uzh.ch; http://www.lifescience-zurich

Expertise:

Institute of Clinical Chemistry (Prof VON ECKARDSTEIN, Dr. HORNEMANN, Dr. ROHRER): basic and clinical research on sphingolipid and high density lipoprotein metabolism to resolve their role in the pathogenesis of diabetes mellitus and its cardiovascular and neurological complications. Specific technological expertise in the analytics of sphingolipids and other lipids as well as testing of HDL functionality. Institute of Veterinary Physiology (Prof. LUTZ): expert in the controls of food intake and in type 2 diabetes mellitus. He and his surgical colleagues Drs BUETER and SCHIESSER (Department of Visceral and Transplantation Surgery) have established bariatric surgery models in rats and mice which will allow studying in detail the role of food intake and of different food components, of the gastrointestinal tract and in particular gastrointestinal hormones in the development of the MetS.

Facilities:

(i) State of the art animal houses for reproduction, maintenance and experimentation of pure inbred, outbred, transgenic and knockout mouse strains. (ii) Functional Genomics Center: joint state-of-the-art research and training facility of UZH and ETHZ offering latest technologies and expert support in genomics, transcriptomics, proteomics, metabolomics, and bioinformatics. (iii) Center for a Clinical Research including a Clinical Trials Center to perform research projects on probands and patients. (iv) Institute of Clinical Chemistry: lipoprotein isolation, cell culture for HDL function testing, mass spectrometers (LC-MS/MS and GC-MS); routine clinical biochemistry testing of humans and animal samples. (v) Institute of Veterinary Physiology: bariatric surgery of small animals (rats, mice) and labs with all necessary equipment allowing physiological testings of food intake controls and controls of energy expenditure. (vi) Department of Visceral and Transplantation Surgery: 150 bariatric surgeries per year as well as many other surgeries of relevance for control experiments.

Other EU Projects:

UZH is involved in many projects (FP6, FP7, ERC, COST). Scientists involved in RESOLVE have been coordinator and partner of: HDLOMICS (FP6-LIFESCIHEALTH 037631) and are Partner and Vice-Chairman of the COST action “HDLnet” (BM903).