Foundation for Research and Technology Hellas (forth) – institute of molecular biology and biotechnology – GR



General description:

The Institute of Molecular Biology and Biotechnology (IMBB) was founded in 1983 and is part of the Foundation of Research and Technology-Hellas (FORTH), one of the largest research centers in Greece.

Research at IMBB is diverse and falls into the following areas: gene regulation, developmental genetics, neurosciences, host-pathogen interactions and immunity, protein function and structural biology. IMBB multidisciplinary research is supported by state-of-the-art experimental facilities and enhanced by extensive collaborations and interactions with the other co-located institutes of FORTH that conduct research in physical, computing and mathematical sciences. Additional scientific interactions and collaborations have been established with many departments at the University of Crete, as well as the broader academic and research community in Greece and the rest of Europe.



Transcriptional regulation of HDL genes under basal or inflammatory conditions in liver and macrophages, focus on the role of hormone nuclear receptors and hepatic transcription factors in HDL metabolism, expertise in structure-function studies in animal models using adenovirus-mediated gene transfer.


(i) State of the art animal house for housing mouse models of dyslipidemia (transgenic and KO). The Animal House at IMBB can house 3000-4000 mice for the reproduction and maintenance of pure inbred, outbred, transgenic and knockout strains. The experienced and helpful technical staff of the Animal House assists the research workers in their animal experiments, and is responsible for proper maintenance of this key facility of the Centre. (ii) Transcriptomics facility to analyze the transcriptome of human and mouse samples as well as the miRNome. This includes: a) A four-color GeneChip Scanner 3000 7G with AutoLoader that is a 16-bit confocal scanner with a solid state 532nm Green Laser. b) Two Fluidics Station 450s that performs washing and staining of the probe arrays in an automated manner. c) One Hybridization Oven 645, that can carry out hybridization of up to 64 arrays at a time; d) A computer workstation with quad-core Xeon processors loaded with Affymetrix GeneChip Command Console Software (AGCC) that drives the 2 fluidic stations and the scanner; e) Pre-amp and post-amp workstations with GeneChip® Targeted Genotyping Analysis Software and also a 2D handheld barcode reader with each workstation for automated data tracking.

Other EU Projects:

(>50 projects): NEURONAGE (Molecular Basis of Neuronal Ageing – FP7-IDEAS – ERC Advanced Grant Interdisciplinary Panel – Project ref: 238186); INFLA-CARE (Understanding Inflammation‐Associated Tumorigenesis for the Rational Design of Novel Anti‐Cancer Therapeutic Strategies – FP7 HEALTH – Project ref: 223151); TRANSMALARIABLOC (Malaria Transmission Blocking by Vaccines, Drugs and Immune Mosquitoes: Efficacy Assessment and Targets – FP7-HEALTH – Project ref: 223736); ProFI (Proteomics Facility at the Institute of Molecular Biology and Biotechnology – FP7-REGPOT – Project ref: 229823); HDLOMICS (Functional Genomics of Inborn and Therapeutic Interventionw of High Density Lipoprotein – FP6-LIFESCIHEALTH – Project ref: 037631).